I've just this week been looking to manage that same high quality problem. For daily charts, what I'm leaning toward is closing half when I get a candle that opens and closes entirely outside 3.0 ATR Keltner Channels.
Luckily, this was something I was thinking about on the weekend as I'm building my swing trading plan. Monday, I got in TLRY on a day trade and decided to let it run since I'm trying to move more into swing trading. The next day it gapped up and I sold half near mid day when it started to come back down. The day after that it opened and closed much higher and I didn't have any plan for what to do with the other half. I went the greedy route and moved my stop up under that giant wick. The next morning it gapped way down and I was stopped out within minutes after the open, 17 points below the previous day's close.
What I'm leaning toward is selling half of the current position on each candle that opens and closes outside 3.0 ATR Keltner Channels and moving my stop under that candle. That way I lock in profits along the way without missing half the move if it keeps running. So, if I had 100 shares, first I would sell 50, then next candle 25, etc. This is just theory at this point. I'm not sure how well it will work out. I only added the Keltner Channels on my charts this week. Maybe 3.0 isn't a good level across many stocks, though it seems to be as I've been keeping an eye on it while looking at charts this week. And even if it is a good level on daily it may not be good on other timeframes.
If you applied this to PACB on the daily chart, the most recent candle is where you would sell the first half and then move up your stop.